Abstract Search

ea0041oc3.2 | Diabetes prediction & complications | ECE2016

Glucose-dependent insulinotropic peptide (GIP) stimulates Glucagon-like peptide (GLP)-1 from human and mouse pancreatic islets partly via alpha-cell-derived IL-6

Timper Katharina , Dalmas Elise , Dror Erez , Rutti Sabine , Thienel Constanze , Sauter Nadine S. , Bouzakri Karim , Bedat Benoit , Pattou Francois , Kerr-Conte Julie , Boni-Schnetzler Marianne , Donath Marc Y.

Introduction: Glucose-dependent insulinotropic peptide (GIP) induces the cytokine interleukin (IL)-6 in adipocytes. IL-6 enhances insulin secretion from β-cells via L- and α-cell-derived GLP-1.Therefore we hypothesized that GIP regulates Glucagon-like peptide (GLP)-1 as well as glucose control via IL-6.Methods/Design: Basic research study on isolated human and mouse pancreatic islets and FACS-sorted human α-and β-cells that were treat...

0 shares

Endocrine Abstracts

Glucose-dependent insulinotropic peptide (GIP) stimulates Glucagon-like peptide (GLP)-1 from human and mouse pancreatic islets partly via alpha-cell-derived IL-6

BiosciAbstracts